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Fanconi syndrome
Fanconi syndrome (also known as Fanconi's syndrome) is a disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine, instead of being reabsorbed. Fanconi syndrome affects the proximal tubule, which is the first part of the tubule to process fluid after it is filtered through the glomerulus. It may be inherited, or caused by drugs or heavy metals.〔(Fanconi Syndrome ) at Merck Manual Home Health Handbook〕
Different forms of Fanconi syndrome can affect different functions of the proximal tubule, and result in different complications. The loss of bicarbonate results in type 2 or proximal renal tubular acidosis. The loss of phosphate results in the bone disease rickets (even with adequate vitamin D and calcium), because phosphate is necessary for bone development.
==Eponym==
It is named after Guido Fanconi, a Swiss pediatrician; this may be a misnomer, since Fanconi himself never identified it as a syndrome; though, as in the case of Goodpasture's syndrome, it is customary to name a syndrome after the first person to note a constellation of symptoms as occurring together.
It should not be confused with Fanconi anemia, a separate disease.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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